Be sure to carefully follow these instructions and ask your doctor if you have any questions. Be sure to ask your doctor if you have any questions about this program. It is very important that you understand and follow all of the requirements. You will not get another prescription unless you follow the instructions for the program. Swallow the capsule whole with a full glass 8 ounces of water or other liquid. Do not crush, break, chew, or suck the capsule. It is very important that you take isotretinoin only as directed by your doctor.
Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects. It is very important that you not share this medicine with anyone else because of the risk of birth defects and other serious side effects.
Different brands may not work the same way. If you refill your medicine and it looks different, check with your pharmacist. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
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Hello there! Remember me. This item is 4 years and 7 months old; some content may no longer be current. Prescribing isotretinoin for patients with acne in primary care Isotretinoin is recommended for patients with moderate acne that produces scarring or distress, or for acne that persists following other treatments.
Please login to save this article. Log in. What do prescribers need to know? Oral isotretinoin is a highly effective treatment for patients with acne that is causing scarring or distress, or that persists following other treatments Low-dose isotretinoin, e.
Preventing pregnancy in women taking isotretinoin Taking isotretinoin during key developmental periods is detrimental. The adverse effects of isotretinoin Retinoic acid is a metabolite of vitamin A which can cause similar adverse effects as excess vitamin A. NZF v Available from: www.
Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol ;— Isotretinoin 5 mg daily for low-grade adult acne vulgaris--a placebo-controlled, randomized double-blind study.
New Zealand data sheet: Isotane. Making sense of the effects of the cumulative dose of isotretinoin in acne vulgaris. Int J Dermatol ;— Isotretinoin: dose, duration and relapse. What does 30 years of usage tell us? Australas J Dermatol ;— Retinoic acid synthesis and signaling during early organogenesis. Cell ;— Isotretinoin: Update on Controversial Issues. J Pediatr Adolesc Gynecol ;—3.
Adverse effects of isotretinoin: A retrospective review of patients started on isotretinoin. JAMA Dermatol ;— Pharmaceutical Claims Collection. If you often forget doses, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine. After a few weeks, your doctor may change your dose of capsules. You may need a higher dose if your acne isn't getting better. You may need a lower dose if you have side effects that bother you.
If you become pregnant during treatment with isotretinoin capsules, stop taking the capsules and tell your doctor as soon as possible. It's very important that you do not get pregnant while you're taking isotretinoin capsules. You'll be asked by your doctor to follow strict rules to prevent pregnancy during treatment and for 1 month afterwards.
Before starting treatment with isotretinoin capsules, women who are able to become pregnant must agree to:. Your doctor will give you a patient reminder card for isotretinoin.
Read this card and the information leaflet that comes with your medicine before you start taking the capsules. Do not breastfeed while you're using isotretinoin capsules. This medicine can get into breast milk and harm your baby. Do not take isotretinoin capsules if you think you're pregnant, you know you're pregnant, or if you're breastfeeding. Men can safely take isotretinoin capsules if they and their partner are trying for a baby, or their partner is pregnant.
Isotretinoin capsules don't seem to damage sperm. Only tiny amounts of isotretinoin get into semen, which is too little to harm the unborn baby. Some medicines and isotretinoin capsules can interfere with each other, and make it more likely that you'll have side effects.
Tell your doctor if you're taking these medicines before you start treatment with isotretinoin capsules :. There's very little information about taking herbal remedies and supplements while you use isotretinoin capsules. Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.
Isotretinoin capsules are only for severe acne. This is acne with lots of pus-filled spots that may affect the back and chest, as well as the face. Isotretinoin capsules help severe acne by reducing the amount of natural oil made by your skin so blocked pores are less likely.
The medicine also kills the bacteria that cause acne, and relieves redness and soreness. Your acne may get worse when you first start treatment with isotretinoin capsules, but will then normally start to improve after 7 to 10 days. A treatment course of isotretinoin capsules usually lasts for 16 to 24 weeks around 4 to 6 months. Acne will normally keep improving for up to 8 weeks after stopping treatment. Isotretinoin capsules are usually only used for people whose acne doesn't improve with other treatments.
But there are other options for some people with severe acne, for example, treatments that use lasers, and other light devices and chemical peels. Isotretinoin used to also come as a gel, known by the brand name Isotrex. In GSK stopped manufacturing Isotrex gel.
This medicine is no longer available in the UK. However there is a gel containing isotretinoin and erythromycin brand name Isotrexin. There are also other gels that contain tretinoin or adapalene. These work in a similar way to isotretinoin gel.
Ask your specialist or a pharmacist for advice about suitable alternatives and the best treatment for your condition. There's no firm evidence to suggest that taking isotretinoin capsules will reduce fertility in either men or women.
However, women are advised not to take isotretinoin capsules if they're pregnant or trying for a baby. This medicine can harm a baby.
It's safe for women to try for a baby from 5 weeks after their treatment with isotretinoin capsules has finished. A pregnancy test will be done after you stop your treatment. Do not donate blood while taking isotretinoin capsules and for at least 1 month after stopping. If your blood is given to a pregnant woman, it may harm her unborn baby.
Isotretinoin capsules can make you feel sleepy and dizzy.
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